Identification and Modulatory Activity Assessment of 2-Hydroxy-3,4,6-trimethoxyacetophenone Isolated fromCroton anisodontusMull. Arg.(Euphorbiaceae)
| Autor: | Henrique Douglas Melo Coutinho, Maria T.A. Oliveira, Raimundo Braz-Filho, Alexandre Magno Rodrigues Teixeira, Irwin Rose Alencar de Menezes, Diniz M. Sena, Paulo Nogueira Bandeira, Hélcio Silva dos Santos, Maria Rose Jane R. Albuquerque, Bruna M de Mesquita |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Chemistry Pseudomonas aeruginosa Plant Science General Medicine Neomycin biology.organism_classification medicine.disease_cause Antimicrobial Croton Microbiology Complementary and alternative medicine Amikacin Staphylococcus aureus Drug Discovery medicine Antibacterial activity Candida albicans medicine.drug |
| Zdroj: | Natural Product Communications. 9:1934578X1400900 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C krusei and C tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a subinhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p < 0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential. |
| Databáze: | OpenAIRE |
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