Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods
| Autor: | Paulo J. Costa, M. Helena Garcia, Filipa C. Santos, Tânia S. Morais |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences 030302 biochemistry & molecular biology Metals and Alloys Rational design Fluorescence General Biochemistry Genetics and Molecular Biology Fluorescence spectroscopy Biomaterials Hydrophobic effect 03 medical and health sciences chemistry Mechanism of action Transferrin Docking (molecular) medicine Biophysics medicine.symptom General Agricultural and Biological Sciences Cytotoxicity 030304 developmental biology |
| Zdroj: | BioMetals. 34:1029-1042 |
| ISSN: | 1572-8773 0966-0844 |
| Popis: | The interaction between human serum transferrin (hTf) and three promising organometallic Ru (II)- (η5-C5H5) derived complexes, that have already shown strong in vitro cytotoxicity towards human cancer cell lines, has been investigated using fluorescence spectroscopic techniques. The results suggested that the formation of Ru-hTf systems involves a dynamic collision. The binding process occurs spontaneously (ΔG |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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