Multidonor bone marrow transplantation improves donor engraftment and increases the graft versus tumor effect while decreasing graft-versus-host disease
| Autor: | Hirshfeld Ester, Yekhtina Zhanna, Michael Y. Shapira, Weiss Lola, Gerlitz Offer, Slavin Shimon |
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| Rok vydání: | 2010 |
| Předmět: |
Oncology
Transplantation medicine.medical_specialty Graft-versus-tumor effect Neoplasm Transplantation business.industry medicine.medical_treatment Transplantation Chimera Hematopoietic stem cell transplantation medicine.disease Surgery surgical procedures operative Graft-versus-host disease Internal medicine medicine Homologous chromosome Transplantation Conditioning business |
| Zdroj: | Transplant International. 24:194-200 |
| ISSN: | 0934-0874 |
| DOI: | 10.1111/j.1432-2277.2010.01169.x |
| Popis: | In partially matched donor transplantation, mandatory T-cell depletion (TCD) increases the risks of rejection/graft failure, relapse, and post-transplant infections. A multi-donor approach was offered to resolve some of these drawbacks. This hypothesis was previously tested in a TCD fully mismatched murine model. However, the effect of multi-donor transplantation (MDT) on graft-versus-host disease (GVHD) and graft versus tumor (GVT) effect were never tested. To assess the safety and efficacy of MDT, we used it in non-TCD transplantation and murine breast carcinoma model. We found that when transplanting non-TCD MDT composed by C57Bl/6 and C3H cells into BALB/c, a consistent trichimerism is established, dominated by C57Bl/6 cells. Following MDT the study animals experienced reduced GVHD compare with those transplanted from C57Bl/6 alone, while the GVT effect was superior. We conclude that MDT may serve as a technique that suppresses GVHD while maintaining the GVT effect. |
| Databáze: | OpenAIRE |
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