Selective Inducers of the Coh-Locus Enhance the Metabolisms of Coumarin- and of Quinoline-Derivatives but Not That of Naphthalenes

Autor:	W. Legrum, F. Feil, B. Hahnemann, S. A. Mangoura, Karl J. Netter, Richard T. Mayer, M. Tegtmeier
Rok vydání:	1991
Předmět:	Chromosome 7 (human) Cytochrome biology Stereochemistry Quinoline Low activity Locus (genetics) Coumarin chemistry.chemical_compound chemistry biology.protein heterocyclic compounds Inducer Gene
Zdroj:	Advances in Experimental Medicine and Biology ISBN: 9781468458794
DOI:	10.1007/978-1-4684-5877-0_46
Popis:	The Coh-locus is a gene area on mouse chromosome 7 which was described first by Wood and Conney in 1974 (Wood, et al.) from breeding experiments. The name was coined because the gene locus was characterized by using coumarin as substrate for cytochrome P-450 (Coh = coumarin 7-hydroxylase). Later Wood and Taylor (1979) distinguished two forms of the locus, one coding for a cytochrome P-450 with low activity towards coumarin (Cohl in B6-mice) and another coding for a high activity variety of the coumarin 7-hydroxylase (Cohh in D2-mice).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::50ed9c1144b3992653efdc5a17a5c51f https://doi.org/10.1007/978-1-4684-5877-0_46 Zobrazit plný text záznamu