Diffusion-weighted hyperpolarized 129 Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease

Autor: Gary P. Cofer, H. Page McAdams, William F. Auffermann, John Nouls, Gregory Metz, Jan Wolber, S. Sivaram Kaushik, Denise Beaver, Bastiaan Driehuys, Monica Kraft, Zackary I. Cleveland
Rok vydání: 2010
Předmět:
Zdroj: Magnetic Resonance in Medicine. 65:1154-1165
ISSN: 0740-3194
Popis: Xe apparent diffusion coefficient (ADC) MRI offers an alternative to 3 He ADC MRI, given its greater availability and lower cost. To demonstrate the feasibility of HP 129 Xe ADC MRI, we present results from healthy volunteers (HV), chronic obstructive pulmonary disease (COPD) subjects, and age-matched healthy controls (AMC). The mean parenchymal ADC was 0.036±0.003 cm 2 /s for HV, 0.043±0.006 cm 2 /s for AMC, and 0.056±0.008 cm 2 /s for COPD subjects with emphysema. In healthy individuals, but not the COPD group, ADC decreased significantly in the anterior-posterior direction by ~22% (p = 0.006, AMC; 0.0059, HV), likely due to gravity-induced tissue compression. The COPD group exhibited a significantly larger superior-inferior ADC reduction (~28%) than the healthy groups (~24%) (p = 0.00018 HV; p = 3.45×10 -5 AMC), consistent with smoking-related tissue destruction in the superior lung. Superior-inferior gradients in healthy subjects may result from regional differences in xenon concentration. ADC was significantly correlated with pulmonary function tests (FEV1, r=-0.77, p=0.0002; FEV1/FVC, r=-0.78, p=0.0002; DLCO/VA, r=-0.77, p=0.0002), and in healthy groups, increased with age by 0.0002 cm 2 /s/yr (r=0.56, p=0.02). This study shows 129 Xe ADC MRI is clinically feasible, sufficiently sensitive to distinguish HV from subjects with emphysema, and detects age and posture-dependent changes.
Databáze: OpenAIRE
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