Structure-based design, synthesis, and profiling of potent and selective neuronal nitric oxide synthase (nNOS) inhibitors with an amidinothiophene hydroxypiperidine scaffold
| Autor: | Jason Jiang, Linli Wei, Randall H. Munson Jr., Roy J. Vaz, Guyan Liang, Mark D. Black, Sharkir Sarhan, Gerardo Francisco, Isabelle Morize, Anthony C. Scotese, Gregory M. Shutske, Kent Neuenschwander, Xin Chen |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Scaffold biology Stereochemistry Chemistry Organic Chemistry Pharmaceutical Science biology.organism_classification Biochemistry Combinatorial chemistry Design synthesis Enos Drug Discovery Molecular Medicine Aliphatic amine Structure based Selectivity Neuronal Nitric Oxide Synthase Linker |
| Zdroj: | MedChemComm. 2:201 |
| ISSN: | 2040-2511 2040-2503 |
| DOI: | 10.1039/c0md00255k |
| Popis: | A novel series of nNOS inhibitors with an amidinothiophene-hydroxypiperidine scaffold was designed based on X-ray structures and in-silico models. Three classes of inhibitors with this scaffold were synthesized and tested for their nNOS activity and eNOS selectivity. Compounds with a linear aliphatic amine linker demonstrated a superior property over those with a sulfonamide or an amide-like linker. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|