Preparation of 4(3H)-quinazolinones from aryldiazonium salt, nitriles and 2-aminobenzoate via a cascade annulation
| Autor: | Shiuh-Tzung Liu, Ming-Tsung Hsu, Mani Ramanathan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Annulation Nitrile 010405 organic chemistry Organic Chemistry Salt (chemistry) 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Cascade Drug Discovery Nitrilium Quinazolinone |
| Zdroj: | Tetrahedron. 75:791-796 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.12.065 |
| Popis: | One-pot synthesis of 3-aryl-4(3H)-quinazolinones has been realized through a cascade annulation. Reaction of aryldiazonium salt with a nitrile provides in situ generation of a reactive nitrilium ion, which is attacked by the amino group of 2-aminobenzoate followed by cyclization to deliver the desired product. This strategy offers a convenient and easy access to a wide range of functionalized quinazolinone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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