1506Flexible parametric survival models investigating factors associated with diabetes-related foot ulcer time-to-healing
| Autor: | Ewan M Kinnear, Rosana E. Pacella, Jaap J. van Netten, Yuqi Zhang, Steven M. McPhail, Qinglu Cheng, Patrick H Derhy, Peter A Lazzarini, Susanna M. Cramb |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | International Journal of Epidemiology. 50 |
| ISSN: | 1464-3685 0300-5771 |
| DOI: | 10.1093/ije/dyab168.753 |
| Popis: | Background Diabetes-related foot ulcers (DFU) take months to heal, reduce patient’s quality-of-life, and induce large healthcare expenditure. Various factors have been identified to influence DFU healing at fixed periods, however, data on factors associated with time-to-healing is scarce. Methods Patients presenting with DFU to Diabetic Foot Services across Queensland, Australia between July 2011 and December 2017 were included and had their demographics, disease history and treatments examined at baseline. Outcome of interest was healing of all ulcers within two-year follow-up time. Time-to-healing and associated factors were examined using flexible parametric survival models, which easily enabled including time-varying coefficients and predicting proportions healed. Results Of 4,709 included patients (median age 63 years, 69.5% male, 10.5% Indigenous), median time-to-healing was 112 days, and 68% healed within two years. Younger age ( Conclusions This study identified novel and confirmatory factors influencing time-to-healing over 24 months in a large real-world cohort of people with diabetes-related foot ulcers. Visualizing the adjusted predicted proportion healed revealed the influence each factor had on healing rates over time. Key messages Flexible parametric survival model provided flexibility in investigating time-varying effects and outcome prediction in those with diabetes-related foot ulcer healing. |
| Databáze: | OpenAIRE |
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