Modification of Cyclodextrins for Use as Artificial Enzymes

Autor:	Valerian T. D'Souza
Rok vydání:	2003
Předmět:	chemistry.chemical_classification Cyclodextrin biology Stereochemistry Artificial enzyme Substrate (chemistry) General Chemistry Flavin group Catalysis Enzyme chemistry biology.protein Molecule Binding site
Zdroj:	Supramolecular Chemistry. 15:221-229
ISSN:	1029-0478 1061-0278
Popis:	The magical powers of enzymes have been attributed to their ability to bind specific substrates and catalyze reactions of the bound substrate. Artificial enzymes synthetically mimic the binding and the catalytic site to produce molecules that are not only smaller in size but also potentially have similar activity to the real enzymes. The main objective of our research is to create artificial redox enzymes by using cyclodextrins as binding sites and attaching flavin derivatives as the catalytic site. We have developed a strategy to attach a catalytic site to cyclodextrin exclusively at the 2-, 3- or the 6-position. The evaluation of the artificial enzyme in which flavin is attached to the 2-position gives a 647-fold acceleration factor. Although this is modest compared to those of real enzymes (which can have acceleration factors of a trillion), the artificial enzymes allow us to understand the elements that contribute to the incredible catalytic power of enzymes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::50d0c0144eddbc24e5fce9f08adbfc0a https://doi.org/10.1080/1061027031000078220 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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