Periodontal disease and risk of mortality and kidney function decline in advanced chronic kidney disease: a nationwide population-based cohort study
| Autor: | Hsiang Ling Wu, Yih Giun Cherng, Wan Chi Liu, Jui Tai Chen, Hsien Cheng Kuo, Ying Hsuan Tai, Mei Yi Wu, Tzeng Ji Chen, Ying Xiu Dai, Wei Jen Chang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Proportional hazards model Hazard ratio Population 030206 dentistry Disease medicine.disease End stage renal disease 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Risk of mortality Medicine business education General Dentistry Kidney disease Cohort study |
| Zdroj: | Clinical Oral Investigations. 25:6259-6268 |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | Periodontal disease is prevalent in patients with chronic kidney disease (CKD) and potentially associated with kidney function decline. However, it is uncertain whether periodontal disease affects the risk of mortality and morbidity in patients with advanced CKD. Taiwan’s National Health Insurance Research Database was used to conduct a nationwide population-based cohort study. Propensity score matching procedures were performed to select people with stage 5 CKD and to compare the long-term risk of mortality, end-stage renal disease, and major adverse cardiovascular events (MACE) between people with and without periodontal disease. Multivariable Cox regression analyses were conducted to calculate the adjusted hazard ratio (aHR) with 95% confidence interval (CI) for the outcome of interest. A total of 8119 subjects with stage 5 CKD were initially included. After matching to demographic and clinical covariates, 1254 subjects with 7099 person-years of follow-up were selected for analyses. Periodontal disease was not associated with long-term risks of all-cause mortality (aHR: 0.77, 95% CI: 0.49–1.22), progression to end-stage renal disease (aHR: 0.91, 95% CI: 0.75–1.10), or MACE (aHR: 1.18, 95% CI: 0.91–1.53). These findings were generally consistent across subgroups of age, sex, comorbid diabetes, uses of systemic antibiotic, and different dental procedures. Periodontal disease is not a predictor for long-term mortality or morbidity in patients with advanced CKD. These results provide important evidence to elucidate the relationship between periodontitis and critical clinical outcomes of advanced CKD. |
| Databáze: | OpenAIRE |
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