Chemical Enhancers or Transcutaneous Conductors: Transcutol

Autor:	O. G. Strusovskaya, A. G. Strusovskaya, S. V. Poroiskii
Rok vydání:	2019
Předmět:	Pharmacology integumentary system 010405 organic chemistry Chemistry Pharmacology toxicology 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry medicine.anatomical_structure Drug Discovery Stratum corneum medicine Enhancer Skin lipid Electrical conductor Biomedical engineering
Zdroj:	Pharmaceutical Chemistry Journal. 52:879-884
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-019-01920-5
Popis:	The concept of enhancers or transcutaneous conductors and their classification and mechanism of action are discussed. Special attention is paid to transcutol, a conductor with pronounced solubilizing and penetrating properties that facilitates the accumulation of locally applied medicines in the skin lipid layer without perturbing its structure. The transcutaneous action effectiveness of chemical enhancers is shown to depend on not only the structure and concentration but also the physicochemical characteristics of the penetrating drugs. Diffusional transport in the stratum corneum and the ability to monitor the occurring processes can be used to optimize the design of drugs for transcutaneous targeted delivery.
Databáze:	OpenAIRE
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