Dopamine D1and D2receptor subtypes functional regulation in corpus striatum of unilateral rotenone lesioned Parkinson's rat model: effect of serotonin, dopamine and norepinephrine

Autor:	Korah P. Kuruvilla, M. S. Nandhu, Jes Paul, C. S. Paulose
Rok vydání:	2010
Předmět:	medicine.medical_specialty business.industry Dopaminergic Substantia nigra General Medicine Endocrinology Dopamine receptor D1 nervous system Neurology Dopamine receptor Dopamine receptor D3 Dopamine Internal medicine TAAR1 Dopamine receptor D2 Medicine Neurology (clinical) business medicine.drug
Zdroj:	Neurological Research. 32:918-924
ISSN:	1743-1328 0161-6412
DOI:	10.1179/016164110x12700393823417
Popis:	Parkinson's disease (PD) is due to widespread degeneration in the central and peripheral nervous systems. The hallmark pathology remains in the dopaminergic striatal insufficiency and degeneration of dopaminergic neurons in the substantia nigra. Objectives: The present study analysed the effect of serotonin (5-HT), dopamine, and norepinephrine as treatment on rotenone induced hemi-Parkinson's disease in rats and its role in the regulation of dopamine receptor subtypes in the corpus striatum of the experimental rats. Methods: Unilateral stereotaxic single-dose infusions of rotenone were administered to the substantia nigra of adult male Wistar rats. Neurotransmitters serotonin (5-HT), dopamine, and norepinephrine treatments were given to rotenone induced hemi-Parkinson's rats. Dopamine receptor and its subtypes (D1 and D2) binding assay were carried out. Gene expression studies of dopamine D1 and D2 were carried out using real-time PCR. Results: Scatchard analysis of dopamine and dopamine D2 recept...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::50c45eec4c855e2614d1b25e2f93d1e3 https://doi.org/10.1179/016164110x12700393823417 Zobrazit plný text záznamu