The relationship between rs1122608 and susceptibility, risk factors, clinical characteristics of acute myocardial infarction in Chinese Han population
| Autor: | Jun Li, Tian Li, Quan-Fang Chen, Wei Wang, Zhou Huang, Fan Wang, Dong Ling Huang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Case-control study Infarction Single-nucleotide polymorphism medicine.disease 03 medical and health sciences 030104 developmental biology Polymorphism (computer science) Internal medicine Genotype medicine SNP Population study cardiovascular diseases Risk factor Cardiology and Cardiovascular Medicine business health care economics and organizations |
| Zdroj: | The Anatolian Journal of Cardiology. |
| ISSN: | 2149-2263 |
| DOI: | 10.14744/anatoljcardiol.2018.35002 |
| Popis: | OBJECTIVE The correlation of the BRG1 rs1122608 single nucleotide polymorphism (SNP) with acute myocardial infarction (AMI) has been reported in American and European populations. However, whether rs1122608 acts as a protective factor or a risk factor for AMI is controversial. In this study, we aimed to detect the associations between rs1122608 and the clinical characteristics of AMI as well as susceptibility, gene-environment interactions, and risk factors for AMI in a Chinese Han population. METHODS In this study, 300 AMI patients and 300 healthy controls of Chinese Han ancestry were enrolled. PCR-RFLP was used to genotype rs1122608 SNPs. Genotypic and allelic frequencies of rs1122608 were compared between the AMI and control groups and among four AMI subgroups, which were subdivided by typical symptom, diagnosis time (DT), infarction location andserious complication. RESULTS Significant differences were detected between the AMI patients and the controls in both the genotypic and allelic frequencies of rs1122608 (p |
| Databáze: | OpenAIRE |
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