Investigation of cell growth on ion beam patterns on GPC surface

Autor:	Daryush Ila, F. Ozdal-Kurt, Ismet Deliloglu Gurhan, Marcos Rodrigues, B. H. Sen, Robert Lee Zimmerman, Claudiu Muntele
Rok vydání:	2009
Předmět:	Materials science Ion beam Cell growth Substrate (chemistry) Surfaces and Interfaces General Chemistry Adhesion Condensed Matter Physics Surfaces Coatings and Films Ion medicine.anatomical_structure Ion implantation Electrode Materials Chemistry medicine Heart valve Biomedical engineering
Zdroj:	Surface and Coatings Technology. 203:2558-2561
ISSN:	0257-8972
DOI:	10.1016/j.surfcoat.2009.02.075
Popis:	We have used implanted silver ions near the surface of Glassy Polymeric Carbon (GPC) to completely inhibit cell attachment and adhesion to GPC. The effect improves the safety and function of the GPC heart valve exposed to the blood stream. The strength, durability and low density make GPC a favored material for in vivo medical applications, including transcutaneous electrodes and replacement heart valves. However, the possible release of endothelial tissue that forms on the smooth surfaces of the GPC heart valve has the potential of creating an embolism. We have shown that L929 endothelial cells avoid silver implanted areas of GPC but attach and strongly adhere to areas close to silver implanted surfaces. Patterned ion implantation permits precise control of tissue growth on GPC and other biocompatible substrates. Cell growth inhibited by silver ion implanted patterns on an otherwise biocompatible substrate may be useful for in vitro studies of the way that cells sense and move away from inhospitable environments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::50b40bb1d95abd05f24e524e903c45db https://doi.org/10.1016/j.surfcoat.2009.02.075 Zobrazit plný text záznamu Full Text from ScienceDirect