| Popis: |
1. 1. A systematic study of various drugs has been made in the treatment of acute experimental pulmonary edema caused by the rapid intracarotid infusion of physiologic salt solution. 2. 2. The following drugs conferred protective effects and tended to prevent the development of edema: 2.1. a. The best results were obtained by hypnotics (phenobarbital, barbital, chloral hydrate) and by combination of any one of the hypnotics with morphine. 2.2. b. A combination of prostigmine with either atropine and curare or atropine and morphine also gave excellent results. 2.3. c. Sympatholytic drugs (ergotamine, 883 F), novocaine, and trasentine gave less constant results. 2.4. d. Vasodilators and drugs stimulating the myocardium only occasionally gave good results. 2.5. e. Atropine, adrenalin, and pitressin definitely made the edema of the lungs worse. 3. 3. Observations on the pathogenesis of acute pulmonary edema caused by the method of rapid intracarotid infusions are drawn from the reported pharmacologic studies. Attention is called to the important part that the central nervous system plays in the syndrome and to reflexes leading to an acute increase of capillary permeability of the lungs. 4. 4. Therapeutic considerations are drawn from the reported experiments. |
