| Popis: |
Introduction: Vortioxetine is a multimodal antidepressant drug that has been reported to have a positive impact on cognition, social function, and fatigue. Nevertheless, it has not been widely studied. Our objective was to explore the effects of vortioxetine on these and other parameters in patients with multiple sclerosis (MS) and depression. background: Vortioxetine is a multimodal antidepressant drug which is able to relieve symptoms of depression. Although it has been reported to have a positive impact on cognition, social functions, and fatigue in genereal population, it has not been widely studied. Patients and methodology: This observational case series study included patients with MS and depression who received treatment with vortioxetine for at least 6 months. The patient history of depression and depressive symptoms was assessed. A neuropsychiatric evaluation was carried out using different scales, both before and after treatment. Results: Of the 25 patients who enrolled in the study, 17 completed the treatment. Significant improvements were observed in health status (EQ-5D; p = 0.002), mood (Beck’s Depression Inventory, BDI-II; p = 0.006), anxiety (State-Trait Anxiety Inventory, STAI-State; p = 0.021, and STAI-Trait; p = 0.011), and in the general health test (Short Form Health Survey, SF-36) for the vitality (p = 0.028) and mental health (p = 0.025) domains of the patients who completed the treatment. However, no statistically significant differences were observed in the cognitive tests related to attention, information processing speed, or fatigue. method: An observational study included patients with multiple sclerosis and depression, who received treatment with vortioxetine for at least 6 months. A history of depression and symptoms of depression were assessed. A neuropsychiatric evaluation was carried out, using different scales, both before and after the patients received the treatment Conclusion: In this population, vortioxetine treatment was effective in reducing the symptoms of depression and improving anxiety, vitality, and mental health. In contrast, it did not produce any improvement in cognition or fatigue but an increase in sample size would be necessary to confirm these results. conclusion: In this population, the treatment with vortioxetine was effective for reducing the symptoms of depression and improving anxiety, vitality and mental health. In contrast, the treatment did not produce any improvement in cognition or fatigue. |
