A practical method for heterogeneously-catalyzed Mizoroki–Heck reaction: Flow system with adjustment of microwave resonance as an energy source
| Autor: | Hiromichi Odajima, Masahiro Mizuno, Tomohiro Ichikawa, Yoshinari Sawama, Shun Ueda, Hironao Sajiki, Noriyuki Ohneda, Yasunari Monguchi |
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| Rok vydání: | 2018 |
| Předmět: |
Permittivity
010405 organic chemistry Chemistry Organic Chemistry Inorganic chemistry 010402 general chemistry 01 natural sciences Biochemistry Toluene 0104 chemical sciences Catalysis chemistry.chemical_compound Cartridge Heck reaction Drug Discovery Acetonitrile Energy source Intensity (heat transfer) |
| Zdroj: | Tetrahedron. 74:1810-1816 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2018.02.044 |
| Popis: | The microwave-assisted and continuous-flow Mizoroki–Heck reaction using a heterogeneous palladium catalyst supported on the anion-exchange resin DIAION WA30 (7% Pd/WA30) is described. The microwave resonance is finely adjusted to 2.4 GHz according to the electric permittivity of the reaction medium for efficient heating. Organic solvents, such as acetonitrile, N,N-dimethylacetamide, and toluene, can be sufficiently heated even with a low intensity of microwave irradiation in a 7% Pd/WA30-packed, glass tube-shaped catalyst cartridge, which was designed based on the electric permittivity of the solvents. The catalyst cartridge can be continuously reused at least 5 runs without exchange. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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