Investigation of natural minerals for ulcerative colitis therapy
| Autor: | Xinxuan Liu, Limei Bai, Huaming Yang, Mei Long, Yi Zhang, Zhiya Sun, Shunxiang Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
biology
020101 civil engineering Geology 02 engineering and technology Pharmacology Natural mineral Gut flora engineering.material 021001 nanoscience & nanotechnology biology.organism_classification medicine.disease Ulcerative colitis Halloysite 0201 civil engineering chemistry.chemical_compound Montmorillonite chemistry Geochemistry and Petrology In vivo medicine engineering 0210 nano-technology Drug carrier Dextran Sulfate Sodium |
| Zdroj: | Applied Clay Science. 186:105436 |
| ISSN: | 0169-1317 |
| DOI: | 10.1016/j.clay.2020.105436 |
| Popis: | Ulcerative colitis (UC) affects millions of people worldwide and is currently incurable. As such, there is an urgent need for effective drugs that will promote UC remission. This study investigated the therapeutic effects of five typical natural minerals on UC induced by dextran sulfate sodium (DSS): kaolinite (Kaol), halloysite (Hal), diatomite (Dia), montmorillonite (Mt), and palygorskite (Pal). These minerals were characterized by lamellar, tubular, columnar porous, and fibrous morphologies, as well as centered size distribution and negative charge. In vivo experiments indicated that natural minerals had a remission effect on UC and altered gut flora, especially Kaol. These results suggest that natural minerals can serve as drugs, or drug carriers, to attain synergistic effects with other drugs for UC therapy. |
| Databáze: | OpenAIRE |
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