Synthesis and anti-HIV-1 Activity of [1-[2′,5′-Bis-O-(Tert-Butyldimethylsilyl)-β-L-Ribofuranosyl]Thymine]-3′-Spiro-5″-(4″-Amino-1″,2″-Oxathiole-2″,2″-Dioxide) (L-TSAO-T), the L-enantiomer of the Highly Specific HIV-1 Reverse Transcriptase Inhibitor TSAO-T
| Autor: | E. De Clercq, Jan Balzarini, M J Camarasa, S. T. Ingate |
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| Rok vydání: | 1995 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Reverse-transcriptase inhibitor biology Stereochemistry 030106 microbiology virus diseases General Medicine 01 natural sciences Chemical synthesis In vitro 0104 chemical sciences Thymine 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound Enzyme chemistry Enzyme inhibitor medicine biology.protein Enantiomer Cytotoxicity medicine.drug |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 6:365-370 |
| ISSN: | 2040-2066 |
| Popis: | The L-isomer of the potent HIV-1-RT inhibitor TSAO-T has been stereospecifically synthesized and tested for its ‘ in vitro’ antiretroviral activity against HIV-1. Unlike the D-isomer, the L-isomer did not show appreciable inhibition of HIV-1 replication. The cytotoxicity was comparable with the cytotoxicity of the D-enantiomer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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