Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid
| Autor: | Stephan Arndt, Peter T. Loosen, E B S Wendell Nicholson, Nosa N. Ekhator, David N. Orth, Thomas D. Geracioti |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Central nervous system Psychiatry and Mental health Clinical Psychology Corticotropin-releasing hormone Cerebrospinal fluid Endocrinology medicine.anatomical_structure Internal medicine Post-hoc analysis medicine Anxiety medicine.symptom Psychology hormones hormone substitutes and hormone antagonists Depression (differential diagnoses) Cholecystokinin Hormone |
| Zdroj: | Depression and Anxiety. 10:77-80 |
| ISSN: | 1520-6394 1091-4269 |
| DOI: | 10.1002/(sici)1520-6394(1999)10:2<77::aid-da7>3.0.co;2-w |
| Popis: | Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the rat central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lacking. A post hoc analysis of serial concentrations of immunoreactive CCK and CRH, obtained every ten minutes from CSF continuously collected over six hours, was performed. A total of 30 subjects were studied: 15 normal volunteers, 10 patients with major depression, and 5 recently-abstinent, alcohol-dependent patients. Overall, we observed an average intra-subject correlation of +.273 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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