Effects of Experimental Hyperthermia on Biodynamics and Immunity in Dogs and Cats
| Autor: | Toyohiko Urakawa, Takashi Hasegawa, Chiyoko Nukuzuma, Manabu Kawata, Hiromu Katamoto, Akira Shibazaki, Kohei Ohtsuka |
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| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | Thermal Medicine. 22:35-48 |
| ISSN: | 1881-9516 0911-2529 |
| DOI: | 10.3191/thermalmedicine.22.35 |
| Popis: | A high-accuracy hot water immersion-type device for hyperthermia has been developed. In order to provide strong evidences that raising body temperature causes heat injuries at higher temperature and enhances immunity at proper combinations of temperature and duration, a series of accurate experimental hyperthermia trials in dogs and cats was carried out using the device. The biological responses to heating were similar in both dogs and cats. A typical sign of heat related injuries, rapid granulocyte collapse (granulocytolysis), was observed while the body was heated at the rectal temperature 42.5°C and more than 42.5°C. In addition, the increase of liver enzymes and the tendency of hemorrhage were notable. Heating at 43.0°C was rather fatal even one hour heating. The degradation of heat shock proteins, HSP90 and Hsc73, was detected on 1 and 3 days post treatment. On the other hand, in the cases of the mild (fever-range) heating less than 42.0°C, the animals were rather stable during the treatment, recovered quickly from anesthesia and showed the good condition and appetite after the treatment. Increase in number and percentage of lymphocytes was remarkable at the proper heating temperature 41.5°C. The enhancement of cellular immunity and the induction of Hsp72 were also confirmed by delayed type hypersensitivity skin test and Hsp72-specific ELISA, respectively. Contrary to our expectations, even the slightly mild heating at the normal body temperature range of these small animals, 38-39°C for 3.5 hours, also provided clear enhancement of immuno-competence. In conclusion, there were no significant differences in biodynamics and immunity in both dogs and cats to heating and we regard fever-range hyperthermia as a mighty immunotherapy. |
| Databáze: | OpenAIRE |
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