| Autor: |
Nora L El-Tantawy, Khalid Abdalaziz, Samar N. El-Beshbishi, Raefa A Atia, Sara M Elzeky |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Parasitologists United Journal. 13:190-196 |
| ISSN: |
2090-2646 |
| DOI: |
10.21608/puj.2020.34614.1079 |
| Popis: |
Background: Toxoplasma gondii is a widespread neurotropic protozoan that influences the CNS physiologywith a potential role in mediating congenital and neurodevelopmental disabilities of children.Objectives: The current study was conducted to investigate the associations between toxoplasmosis andneurodevelopmental disorders in children and to analyze the possible risk factors.Patients and Methods: In this case control study, serum samples from 120 children with neurologicaldisorders and 120 healthy control children were investigated for anti-Toxoplasma IgM and IgG antibodiesusing the enzyme-linked immunosorbent assay (ELISA). Demographics, maternal and children risk factorsand developmental data of children were recorded.Results: The seropositivity rates of both IgM and IgG anti-Toxoplasma antibodies were higher in thechildren group with neurodevelopmental disorders than the control group with significant difference.Statistically significant associations were found between Toxoplasma IgG seropositivity and childrenmanifesting hydrocephaly, microcephaly, and Down syndrome. While anti-Toxoplasma IgM seropositivitywas significantly associated with children manifesting epilepsy and Down syndrome. Contact with soiland farm animals was found to be a significant risk factor for toxoplasmosis in this study.Conclusion: The findings denote that toxoplasmosis is a probable risk factor for neurodevelopmentaldisorders in children. This highlights the importance of toxoplasmosis consideration by pediatricians forinvestigating and early management of such congenital and neurodevelopmental disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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