| Popis: |
Lungs are the vital organ for the respiration which is located on either side of the thorax. Respiration is the rhythmical process of breathing, in which air is drawn into the alveoli of the lungs via inhalation and subsequently expelled through exhalation. Chronic Obstructive Pulmonary Disease (COPD) (includes emphysema, chronic bronchitis), Asthma, Cystic Fibrosis, and Bronchiectasis are the most clinically reported problems related to lungs. COPD is a health condition, where air sacs either destructs or enlarges in case of emphysema and chronic bronchitis results from inflammation or narrowing of bronchial tubes. Aerosol drug therapy is one of the efficient way to deal with COPD. To clear out the airway passages, the drug can be inhaled by mouth and the drug will pass through trachea and bronchi and finally it will set down in lungs. The amount of drug deposition is the resultant of the following factors: aerosol diameter, inhaling velocity, airway geometry and age of the patient. This research focuses on developing a unique three-dimensional CAD model with double bifurcation and three generation for assessment of bronchial region condition based on Weibel convention. The analysis is performed for two-phase system where air is the medium to carry aerosol particles. The CAD model is analyzed with CFD method and the outcome will be correlation between deposition fractions vs. aerosol diameter for air volume flow. |
