Tributyltin(IV)[3-(3′,5′-dimethylphenylamido)propanoate] as a potent HCV inhibitor, its delivery study, controlled release and binding sites using CTAB as a standard cell membrane

Autor:	Kaneez Fatima, Shaista Sabir, Saqib Ali, Ishtiaq Qadri, Farooq Ali Shah
Rok vydání:	2013
Předmět:	biology Chemistry Stereochemistry General Chemistry biology.organism_classification Controlled release Micelle Inorganic Chemistry Gaussia chemistry.chemical_compound Membrane Bromide Tributyltin Solubility IC50 Nuclear chemistry
Zdroj:	Applied Organometallic Chemistry. 28:74-80
ISSN:	0268-2605
DOI:	10.1002/aoc.3079
Popis:	Gaussia luciferase assay was used to measure the anti-hepatitis C (anti-HCV) potency of tributyltin(IV)[3-(3′,5′-dimethylphenylamido)propanoate] in infected Huh 7.5 cells (human hepatocellular cell). Interaction of the organotin(IV) complex with cetyl N,N,N-trimethylammonium bromide (CTAB) micelles was studied using UV–visible and steady-state florescence spectroscopy. The anti-HCV study showed a log IC50 value of 0.96 nm for the complex. The complex–CTAB interaction parameter showed that partition of the complex from bulk water to the CTAB micelle was a spontaneous process, and the red shift in visible spectra of the complex confirmed its increased solubility into micelles. Copyright © 2013 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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