Citral: antifungal activity and mode of action, against Cladosporium oxysporum

Autor: Edeltrudes de Oliveira Lima, Cássio Ilan Soares Medeiros, Lilian Sousa Pinheiro, Camilla Pinheiro de Menezes, Abrahão Alves de Oliveira Filho, Ana Luíza Alves de Lima Pérez, Janiere Pereira de Sousa
Rok vydání: 2020
Předmět:
Zdroj: Ciência e Natura. 42:e54
ISSN: 2179-460X
0100-8307
DOI: 10.5902/2179460x39693
Popis: Dematiaceous fungi are a group of fungi with dark colonies and pigmented fungal elements. The spectrum of diseases associated with fungi ranges from superficial skin and soft tissue infections to disseminated sepsis with high mortality. Therefore, it is necessary to study molecules with an antifungal action against these fungis. Attention has been drawn to the antimicrobial activity of aromatic compounds because of their promising biological properties. Citral is a monoterpene with known pharmacological properties, including antimicrobial action. Therefore, we investigated the antifungal activity of citral against strains of C. oxysporum, which involved determining its minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and effects on mycelial growth and conidial germination. The effects of citral on the cell wall (sorbitol protect effect) and the cell membrane (citral to ergosterol binding) were investigated. Citral inhibited the growth of 50% of C. oxysporum strains employed in this study at an MIC 128μg/mL, as well as mycelial growth and conidia germination.
Databáze: OpenAIRE
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