A model of deep experimental hypothermia and rewarming in rat

Autor:	J. Palomeque, Norma Alva, Teresa Carbonell
Rok vydání:	2004
Předmět:	Physiology business.industry Cellular respiration Blood flow Acid–base homeostasis Portal vein flow Hypothermia Biochemistry Animal model Anesthesia Breathing Medicine medicine.symptom General Agricultural and Biological Sciences business Developmental Biology
Zdroj:	Journal of Thermal Biology. 29:259-264
ISSN:	0306-4565
DOI:	10.1016/j.jtherbio.2004.04.001
Popis:	We studied the effects of deep hypothermia and rewarming on hepatic regional blood flow, acid–base balance and level of plasma transaminases in rat. A high mortality was found when rewarming at 0.35°C/min. At a rate of 0.25°C/min, all animals survived and the decrease in portal vein flow induced by hypothermia was restored. The reduced blood flow did not affect aerobic metabolism based on lactate levels. In this animal model, pH was maintained by controlling ventilation following the alpha-stat strategy. It appears that deep hypothermia protocol could be safely used to rewarm hypothermic subjects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::50494411abab18cf917b61275f584943 https://doi.org/10.1016/j.jtherbio.2004.04.001 Zobrazit plný text záznamu Full Text from ScienceDirect