Synthesen in der Vitamin-A2-Reihe. 3. Mitteilung. Anwendung der WITTIG-Reaktion zur Synthese von all-trans- und 13-cis-Vitamin A2

Autor:	Rudolf Ruegg, C. V. Planta, Ulrich Schwieter, Otto Isler
Rok vydání:	1962
Předmět:	Hydride Organic Chemistry Vitamin a acid Biochemistry Medicinal chemistry Catalysis Inorganic Chemistry chemistry.chemical_compound chemistry Bromide Drug Discovery Wittig reaction HAMLET (protein complex) Physical and Theoretical Chemistry Vitamin A2
Zdroj:	Helvetica Chimica Acta. 45:541-548
ISSN:	0018-019X
DOI:	10.1002/hlca.19620450217
Popis:	Vitamin A2 acid (m. p. 176–178°) has been prepared by the Wittig reaction of (dehydro-β-ionylidene-ethyl)-triphenylphosphonium bromide and n-butyl β-formyl-crotonate. Reduction of this acid with lithium-aluminium hydride gave a mixture of all-trans- and 13-cis-vitamin A2, which could be separated by chromatography. The same mixture has been obtained from vitamin A acid according to the first vitamin A2 synthesis by FARRAR, HAMLET, HENBEST & JONES.
Databáze:	OpenAIRE
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