Utilization of L-serine in an oxime olefin cycloaddition route to a functionalized asymmetric pyrrolidine, a selective α-glucosidase inhibitor

Autor:	Eliezer Falb, Hugo E. Gottlieb, Abraham Nudelman, Alfred Hassner, Amnon Albeck
Rok vydání:	1994
Předmět:	Olefin fiber Intramolecular reaction Stereochemistry Organic Chemistry Enantioselective synthesis Oxime Biochemistry Pyrrolidine Cycloaddition Serine chemistry.chemical_compound chemistry Drug Discovery Hydroxymethyl
Zdroj:	Tetrahedron Letters. 35:2397-2400
ISSN:	0040-4039
DOI:	10.1016/0040-4039(94)85229-4
Popis:	A new route for asymmetric aza-sugar analogs starting with L-serine and utilizing an intramolecular oxime olefin cycloaddition has been successfully developed. A member of this family of branched chain sugar amino di(hydroxymethyl) pyrrolidines ( 1 and 2 ) exhibits selective inhibition of α-glucosidase, while no inhibition of β-glucosidase was detected.
Databáze:	OpenAIRE
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