Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging

Autor:	I. G. Agafonova, Taisiya V. Moskovkina
Rok vydání:	2015
Předmět:	medicine.diagnostic_test biology Chemistry medicine.drug_class Alkaloid Magnetic resonance imaging Pharmacology medicine.disease Mr imaging Atomic and Molecular Physics and Optics Anti-inflammatory medicine biology.protein Cyclooxygenase Colitis Dextran sodium sulfate
Zdroj:	Applied Magnetic Resonance. 46:781-791
ISSN:	1613-7507 0937-9347
Popis:	The action of tryptanthrin, a known natural alkaloid, a potent inhibitor of cyclooxygenase COX-2 and 5-lipoxygenase, was studied in a model of dextran sodium sulfate (DSS)-induced mouse colitis by magnetic resonance imaging (MRI). It was shown that the intra-ventricular treatment with tryptanthrin suspensions or emulsion at a dose of 25 mg/kg effectively diminishes lethality at experimental groups and normalizes morphometric parameters of intestine in the treated animals. MR imaging confirmed anti-inflammatory effect of this alkaloid and its capability to decrease the size of bowel walls in animals with colitis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::503e3e0aaaefee33b964e5f44327262e https://doi.org/10.1007/s00723-015-0674-3 Zobrazit plný text záznamu Full text from SpringerLink