p,p′-DDT induces microcytic anemia in rats
| Autor: | Makio Takeda, Aya Ohnuma-Koyama, Mariko Tomita, Tomoki Fukuyama, Ryoichi Ohtsuka, Satoru Yamaguchi, Nobuaki Nakashima, Toshinori Yoshida, Maki Kuwahara, Takanori Harada, Sayuri Kojima, Naofumi Takahashi, Junko Fukumori, Yukiko Takeuchi-Kashimoto, Tadashi Kosaka |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty medicine.diagnostic_test Anemia Microcytic anemia Microcytosis Toxicology medicine.disease Dose–response relationship medicine.anatomical_structure Endocrinology Reticulocyte chemistry Transferrin Internal medicine parasitic diseases medicine Hemoglobin Mean corpuscular volume |
| Zdroj: | The Journal of Toxicological Sciences. 38:775-782 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.38.775 |
| Popis: | Emerging evidence suggests that chronic exposure to DDT and its derivatives is associated with a variety of human disorders such as anemia. The present study demonstrated that p,p'-DDT caused microcystic anemia in a dose-dependent manner (0, 5, 50, and 500 ppm) in the long-term study up to 2 years. To elucidate the mechanism(s) by which p,p'-DDT induces anemia, certain hematological parameters were assessed in rats fed specific doses of p,p'-DDT for 2 weeks, and the effect of lipopolysaccharide on anemia of inflammation was also examined in p,p'-DDT-treated rats. The parameters included the content of hemoglobin per reticulocyte, mean corpuscular volume of reticulocytes and mature erythrocytes, corpuscular hemoglobin concentration mean of mature erythrocytes, and saturation levels of transferrin and iron. During the 2-week treatment period, hypochromic microcytic reticulocytes and hypochromic normocytic mature erythrocytes were observed in p,p'-DDT-treated rats, with no evidence of alteration in plasma iron levels. p,p'-DDT enhanced microcytosis of reticulocytes, as well as mature erythrocytes, which occurred due to severe hypoferremia resulting from anemia of inflammation; however, plasma iron levels were attenuated probably through the inhibition of interleukin-6. Our data suggests that long-term treatment with p,p'-DDT induces microcytic anemia, possibly because of the impairment of iron utility in erythrocytes. |
| Databáze: | OpenAIRE |
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