Mixed-ligand manganese(II)-phenolate complexes: study of DNA cleavage, cytotoxic activity, and induction of apoptosis

Autor:	Lin Lin, Yan-Jin Zhang, Mingchang Zhu, Ren-Shu Wang, Mei-Lin Wang, Lei Dai, Wen-Xuan He, Ying Zhang, Qi Liang, En-Jun Gao, Lei Liu
Rok vydání:	2011
Předmět:	Gel electrophoresis chemistry.chemical_classification biology Stereochemistry Carboxylic acid chemistry.chemical_element Manganese Cleavage (embryo) biology.organism_classification HeLa Crystallography chemistry.chemical_compound chemistry Apoptosis Materials Chemistry Physical and Theoretical Chemistry Cytotoxicity DNA
Zdroj:	Journal of Coordination Chemistry. 64:3992-4005
ISSN:	1029-0389 0095-8972
DOI:	10.1080/00958972.2011.634910
Popis:	Two manganese complexes, [Mn(L1)2(dibe)2](L1) (1) and [Mn(L2)2(dibe)2] (2) (where L1 = 2,2′-bipyridine (bipy), L2 = 1,10-phenanthroline (phen)), were synthesized by using a carboxylic acid ligand (dibe = 2,2-dibenzylmalonate acid). The two complexes were characterized using IR, elemental analysis, and X-ray crystallography. Fluorescence analysis indicates that the two complexes can bind to HeLa cell DNA (HC-DNA), and gel electrophoresis assay demonstrates the ability of the complexes to cleave the HC-DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, apoptotic tests demonstrate that these two complexes have apoptotic effects on HeLa cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::503142f086691978639a4ad0bbc20eae https://doi.org/10.1080/00958972.2011.634910 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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