Apoptosis of blood lymphocytes in autoimmune thyropathies

Autor:	Iu V Nedosekova, Kravets Eb, Rogaleva Av, O. I. Urazova
Rok vydání:	2010
Předmět:	medicine.medical_specialty Necrosis Elevated level business.industry Endocrinology Diabetes and Metabolism Disease Fas receptor Endocrinology Apoptosis Internal medicine Immunology medicine In patient Tumor necrosis factor alpha Euthyroid medicine.symptom business
Zdroj:	Problems of Endocrinology. 56:16-20
ISSN:	2308-1430 0375-9660
DOI:	10.14341/probl201056316-20
Popis:	This paper reports the results of a study of lymphocyte apoptosis in the blood of 81 patients presenting with autoimmune thyropathies, such as autoimmune thyroidism (AIT) and Grave's disease (GD). It was shown that AIT in patients with hypothyroidism and DTG is associated with an increased number of CD95+ lymphocytes «doomed» to apoptose. Moreover, AIT and DTG conditions are characterized by an elevated level of serum tumour necrosis factor-alpha (TNF-α). In euthyroid patients with AIT, this rise is accompanied by a decrease in the interferon-gamma (IFN-γ) level. Hypotyroid patients with AIT exhibit positive relationship between an increased number of CD95+ lymphocytes in blood and serum TNF-α levels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5017d8e80a7126029a2190ce9172994e https://doi.org/10.14341/probl201056316-20 Zobrazit plný text záznamu