Des-Phe-insulinhaltiges Intermediärinsulin im Vergleich mit handelsüblichen Präparaten

Autor:	Sachse G, Federlin K, Schäfer D, Mäser E
Rok vydání:	2008
Předmět:	medicine.medical_specialty Chemistry Depot Insulin medicine.medical_treatment nutritional and metabolic diseases Blood sugar Good control Porcine insulin Phenylalanine General Medicine Metabolism Endocrinology Internal medicine medicine tissues hormones hormone substitutes and hormone antagonists
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 107:332-335
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069928
Popis:	In 20 type I diabetics comparison were made between Optisulin -depot CS (25% dissolved porcine Des-Phe-insulin/insulin and 75% crystalline porcine insulin), an intermediary insulin without depot additives, and two depot-additive containing insulins (Depot Insulin Hoechst CS and insulin Leo Mixtard) during a period of hospitalization. Des-Phe-insulins are insulins in which phenylalanine has been split off from the B chain of insulin. Since mixtures of Des-Phe-insulins with crystalline insulins are stable, there is the possibility of manufacturing monospecies-intermediary insulins without depot additives. Continued surveillance of blood sugar during application of Optisulin depot CS showed good control of the diabetic metabolism when compared with the commercially available insulins. Optisulin depot CS in its action is comparable to the two commercially available depot insulins. Side effects and allergic skin changes did not occur. Thus Optisulin depot SC adds to the at present available range of Des-Phe-insulin-containing insulins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::501215692c8d52bec38ce6b8a80bec8c https://doi.org/10.1055/s-2008-1069928 Zobrazit plný text záznamu