Behavioral Characteristics of Mice with Knockout of the IRR Alkali Sensor Gene
| Autor: | A. A. Mozhaev, E. A. Zubkov, Alexander G. Petrenko, Natalia A. Chachina, D. M. Shayakhmetova, I. E. Deyev, A. Yu. Morozova, Vladimir P. Chekhonin |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030102 biochemistry & molecular biology General Neuroscience Insulin medicine.medical_treatment Central nervous system Biology Receptor tyrosine kinase 03 medical and health sciences 030104 developmental biology Endocrinology medicine.anatomical_structure Internal medicine Knockout mouse medicine Cell medium biology.protein Receptor Gene Behavioural despair test |
| Zdroj: | Neuroscience and Behavioral Physiology. 48:483-487 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-018-0589-1 |
| Popis: | The tyrosine kinase receptor IRR (insulin receptor-related receptor) can be activated on alkalinization of the cell medium. IRR is detected in organs in contact with fluids with extreme pH values, as well as in certain central nervous system cells, where its role is unclear. We report here our analysis of the behavioral characteristics of mice with knockout of the IRR gene in a series of ethological tests. The control group included animals with the IRR gene from the same litters as knockout mice. In the social interest test, knockout animals showed a reduction in the number of social contacts. The forced swimming test revealed no statistically significant differences in the duration of immobility, though there were more animals showing longer periods of immobility among knockout mice. In the resident-intruder test, wild-type mice showed typical aggression levels, while seven of 16 knockout animals remained inert and, conversely, were attacked by the “stranger.” These data provide evidence that deletion of the IRR gene leads to impairment of the aggressive-defensive behavior typical of the parental strain. |
| Databáze: | OpenAIRE |
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