Improvement of skin conditions by ingestion of Aspergillus kawachii (Koji) extract containing 14-dehydroergosterol in a randomized, double-blind, controlled trial
| Autor: | Shigehito Ikushima, Mika Miyake, Takayoshi Kirisako, Yukihiro Yada, Yoshihiko Sugihara, Daisuke Fujiwara |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Transepidermal water loss integumentary system Visual analogue scale business.industry Dermatology Placebo law.invention Double blind 03 medical and health sciences 030104 developmental biology Animal science medicine.anatomical_structure Randomized controlled trial law Stratum corneum medicine Ingestion business Aspergillus kawachii |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology. 11:115-124 |
| ISSN: | 1178-7015 |
| DOI: | 10.2147/ccid.s152979 |
| Popis: | Purpose The present study examined the effect of ingestion of Koji extract containing 14-dehydroergosterol (14-DHE), prepared from Aspergillus kawachii NBRC4308, on improvement of skin conditions among healthy volunteers. Subjects and methods In a randomized, double-blind, placebo-controlled, parallel-group study, 70 healthy adult women who felt that their skin was dry ingested either a placebo dietary supplement or Koji extract (200 mg/day) supplement containing 0.1% 14-DHE for 12 weeks. Throughout the treatment period and for 4 weeks afterward, objective indicators - including moisture content of the stratum corneum, trans-epidermal water loss (TEWL), and skin wrinkles - were evaluated; in addition, the subjects answered a questionnaire on their skin conditions with ratings on a visual analog scale. Statistical analysis was conducted on the basis of differences from baseline scores. Results Compared with the placebo group, the Koji extract group showed significantly increased forearm moisture at 4, 8, and 16 weeks (p < 0.05 on unpaired t-test). The questionnaire survey showed a marked improvement in skin conditions, particularly crow's feet, in the Koji extract group versus the placebo group at 8 weeks (p < 0.05 by unpaired t-test). Furthermore, the Koji extract group showed a trend (p < 0.10) toward improvement in skin moisture (at 4 weeks), dryness around the eyes/mouth (at 4 weeks), and overall skin condition (at 8 weeks) versus the placebo group. Conclusion Ingestion of Koji extract containing 14-DHE was demonstrated to have positive effects toward improving skin conditions - in particular, on increasing skin moisture in the stratum corneum. |
| Databáze: | OpenAIRE |
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