Immunotoxicological Investigation of 1-furan-2-yl-3-pyridin-2-yl-propenone in Female BALB/c Mice
| Autor: | Eung-Seok Lee, Tae-Cheon Jeong, Chun-Hwa Kim, Gyu-Sub Ko, Hyun-Woo Ha, Hye Gwang Jeong, Tae Won Jeon, Sangkyu Lee, Mi-Jeong Kang, Jin Woo Yoo, Wonku Kang |
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| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
biology 1-furan-2-yl-3-pyridin-2-yl-propenone medicine.medical_treatment biology.organism_classification Biochemistry BALB/c Nitric oxide chemistry.chemical_compound Immune system Cytokine chemistry Drug Discovery Immunology Splenocyte medicine Molecular Medicine Thymus weight Tumor necrosis factor alpha |
| Zdroj: | Biomolecules and Therapeutics. 17:446-454 |
| ISSN: | 1976-9148 |
| Popis: | 1-Furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) has recently been synthesized and characterized to have an anti-inflammatory activity through the inhibition of the production of nitric oxide and tumor necrosis factor-. In the present study, adverse effects of FPP-3 on immune functions were determined in female BALB/c mice. When mice were administered orally with FPP-3 at 125, 250 or 500 mg/kg for 7 consecutive days, FPP-3 suppressed the number of antibody-forming cells and reduced thymus weight at 500 mg/kg. In addition, FPP-3 administered mice exhibited reduced splenic cellularity and numbers of splenocyte subsets, such as cells, cells, cells and macrophages. IL-4 mRNA expression was significantly suppressed by FPP-3 treatment. Moreover, the number of cells was reduced following the treatment of mice with 500 mg/kg of FPP-3. These results suggested that FPP-3 at 500 mg/kg might be immunotoxic, and that FPP-3-induced immunotoxicity might be mediated, at least in part, through the inhibition of cytokine production, such as IL-4. |
| Databáze: | OpenAIRE |
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