Interaction of transforming growth factor-alpha and epidermal growth factor receptor in breast carcinoma. An immunohistologic study
| Autor: | Rudy J. Castellani, John D. Crissman, Fazlul H. Sarkar, Daniel W. Visscher, S. Wykes |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty TGF alpha Growth factor medicine.medical_treatment Biology Oncology Epidermal growth factor medicine biology.protein Growth factor receptor inhibitor Epidermal growth factor receptor Autocrine signalling Breast carcinoma Transforming growth factor |
| Zdroj: | Cancer. 73:344-349 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19940115)73:2<344::aid-cncr2820730218>3.0.co;2-y |
| Popis: | Background. Interaction of transforming growth factor-alpha (TGF-α) with its receptor, epidermal growth factor receptor (EGFR), has been implicated as an autoregulatory autocrine mechanism of breast epithelial proliferation. Methods. To examine the interrelationship and clinical relevance of TGF-α and EGFR in breast carcinoma, methanol-fixed cryostat sections from 73 patients were immunostained with monoclonal antibodies to epidermal growth factor (EGF), EGFR, and TGF-α. Results. Neither EGFR nor TGF-α staining was diagnostic or specific for the detection of malignant neoplastic cells. Both exhibited staining along the basal lamina of most benign ducts and lobules |
| Databáze: | OpenAIRE |
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