Synthesis and anticholinesterase activities of novel glycosyl benzoxazole derivatives

Autor:	Wang Youxian, Zhiling Cao, Shu-Ting Ren, Lei Wang, Da-Hua Shi, Yu-Ran Wu, Wei-Wei Liu, Shu-Hao Liu
Rok vydání:	2020
Předmět:	Reaction conditions chemistry.chemical_compound Nucleophilic addition chemistry Glucosamine Isothiocyanate Organic chemistry Glycosyl General Chemistry Benzoxazole Tetrahydrofuran
Zdroj:	Journal of Chemical Research. 44:363-366
ISSN:	2047-6507 1747-5198
DOI:	10.1177/1747519819901251
Popis:	Eight glycosyl benzoxazole derivatives are synthesized by nucleophilic addition reactions of glycosyl isothiocyanate with o-aminophenol in tetrahydrofuran. The reaction conditions are optimized, and good yields (86%–94%) were obtained. The structures of all new products are confirmed by infrared, 1H nuclear magnetic resonance, and high-resolution mass spectrometry (electrospray ionization). In addition, the in vitro cholinesterase inhibitory activities of these new compounds are tested by Ellman’s method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4fe43f469ac6fec14f91c7bc6aed5bb2 https://doi.org/10.1177/1747519819901251 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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