Detection of African Trypanosomes Using Asymmetric Double-Split Ring Based THz Sensors

Autor:	Matthias Maasch, H. Ulrich Göringer, Robert A. Knieb, Christian Damm, Mario Mueh
Rok vydání:	2017
Předmět:	Radiation Materials science business.industry Terahertz radiation Aptamer Resonance Ring (chemistry) Resonator Sensor array Electronic engineering Optoelectronics Radiology Nuclear Medicine and imaging Radio frequency Sensitivity (control systems) business Instrumentation
Zdroj:	IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 1:66-73
ISSN:	2469-7257 2469-7249
Popis:	Human African Trypanosomiasis is a highly dangerous tropical disease for which no fast, reliable, and sensitive screening tests are available to date. In this paper, the foundation of a novel electromagnetic sensor concept for aptamer-based direct detection of African trypanosome parasite layers is examined. Special attention is given to the sensitivity of asymmetric double-split ring resonators regarding different resonance modes in dependence on ring gap and target film dimensions. A specific sensor array design is then prototyped and tested using photoresist and actual trypanosome parasite coatings. Its response to different types and mixtures of cells in buffer solution is examined in detail to determine detectability of the parasite in varying dielectric contrast.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4fd86bd8480a733a6c16bef241e9efe8 https://doi.org/10.1109/jerm.2017.2771152 Zobrazit plný text záznamu