ORIGINAL ARTICLE: Abnormal Pattern of Lymphocyte Subpopulations in the Endometrium of Infertile Women with Chronic Endometritis
| Autor: | Piergiorgio Rosenberg, Ettore Cicinelli, T. Falagario, Giorgina Specchia, Domenico Baldini, Pantaleo Greco, Maria Matteo, Laura Castellana, Francesca Massenzio, Arcangelo Liso |
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| Rok vydání: | 2009 |
| Předmět: |
Infertility
Gynecology medicine.medical_specialty medicine.diagnostic_test business.industry Immunology Female infertility Obstetrics and Gynecology medicine.disease Endometrium medicine.anatomical_structure Reproductive Medicine Follicular phase medicine Immunology and Allergy Endometritis business Chronic Endometritis Endometrial biopsy Unexplained infertility |
| Zdroj: | American Journal of Reproductive Immunology. 61:322-329 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2009.00698.x |
| Popis: | Problem Endometrial lymphocytes play a critical role in endometrial receptivity. This study aimed at evaluating the variations induced by chronic endometritis (CE) on endometrial lymphocyte subsets. We compared the results in infertile women diagnosed with CE with those in unexplained infertile women without any sign of CE. Method of study Twenty-three women referring for unexplained infertility had hysteroscopy and endometrial biopsy in the follicular phase; in nine women, CE was diagnosed (group CE+), while in 14 it was not (group CE−). All patients in the late secretory phase of the subsequent cycle underwent endometrial biopsy. By flow cytometry, the percentage and phenotype of the endometrial lymphocyte subpopulations were analyzed. Results The secretory endometrium of patients with CE displayed significantly lower percentage of CD56+ CD16− and of CD56bright CD16− cells (47.8% ± 18.6 and 30.1% ± 20.5 versus 79.5% ± 3.9 and 67.3% ± 8.1, respectively; P |
| Databáze: | OpenAIRE |
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