Pre-micro RNA polymorphism detection in small versus large vessel disease in stroke Egyptian patients
| Autor: | Alaa A. Alzahaby, Hala M. El-Khawas, Ekrami A. Hassan, Hossam M. Shokri, H H Afify, Mustafa M. M. Elbakry |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology Population Single-nucleotide polymorphism Disease Biochemistry 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Polymorphism (computer science) Internal medicine microRNA medicine cardiovascular diseases education Stroke education.field_of_study business.industry medicine.disease body regions 030104 developmental biology embryonic structures Ischemic stroke Cardiology Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Metabolic Brain Disease. 36:1361-1367 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-021-00723-6 |
| Popis: | Stroke is the main cause of adult disability and is responsible for around 11% of deaths all over the world. Ischemic stroke encompasses about 80–85% of total stroke cases. Several studies have shown the relation between microRNAs polymorphism and ischemic stroke. The aim of the study was to evaluate the influence of three common single nucleotide polymorphisms in pre-miRNAs (hsa-miR-146a/rs2910164, hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444) on individual susceptibility to the risk of ischemic stroke subtypes in Egyptian population with 117 ischemic stroke patients. Results showed that hsa-miR-146a/rs2910164 was significantly associated with the risk of small vessel disease stroke in Egyptian population with no significant association between hsa-miR-196a2/rs11614913 and hsa-miR-499/rs3746444 with the risk of ischemic stroke. Therefore, it can be concluded that miR-146a/rs2910164 polymorphism is involved in the vulnerability to small vessel disease ischemic stroke risk in Egyptian population. |
| Databáze: | OpenAIRE |
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