Accelerated Epithelium-Off Corneal Collagen Cross-Linking For Keratoconus: 12-Month Results

Autor:	Ismail Ahmed Nagib Omar, Hosny Ahmed Zein
Rok vydání:	2019
Předmět:	Baseline values Coma Keratoconus medicine.medical_specialty Visual acuity genetic structures business.industry Corneal collagen cross-linking Mean age medicine.disease eye diseases 03 medical and health sciences Ophthalmology Aberrations of the eye 0302 clinical medicine 030221 ophthalmology & optometry medicine In patient sense organs medicine.symptom business 030217 neurology & neurosurgery
Zdroj:	Clinical Ophthalmology. 13:2385-2394
ISSN:	1177-5483
DOI:	10.2147/opth.s232118
Popis:	Purpose The main aim of the study was to report visual, refractive, topographic, and aberrometric results of accelerated CXL in patients with keratoconus who were followed for 12 months and to highlight the important parameters that can be used in follow-up. Settings It was a prospective interventional non-randomized case series study, in which 40 keratoconus eyes of 40 patients were studied in the period between April 2016 and July 2018. Methods All eyes were examined preoperatively and post-accelerated CXL to evaluate visual acuity, refractive state, keratometric values, keratoconus indices, and corneal higher order aberrations (HOAs). Results The mean age of the studied patients was 28.4 ± 8.6 years (18-37years). One year after cross-linking, 11.6% of the eyes gained two lines of the UCVA, 26.4% of the eyes gained one line, 49.8% showed no change, 7.1% lost one line, and 5.1% lost two lines. Postoperative BCVA showed 13.7% of the eyes gained at least two lines, 32.5% gained one line, 49.9% had no change, and 3.9% lost one line. The keratometric values changed significantly after CXL; K1 decreased by a mean of 0.41D, K2 by 0.62D while Kmax by 1.57 D. The significant changes in keratoconus indices were in index of vertical asymmetry (IVA), index of surface variance (ISV), and keratoconus index (KI). Vertical coma, spherical aberrations, and trefoil decreased significantly at 12 months compared to baseline values (p = 0.04, 0.017, 0.025, respectively). Conclusion Keratoconus indices especially ISV, IVA, and KI along with HOAsparticularly vertical coma, spherical aberrations, and trefoil can add value beside keratometric readings in the follow-up of eyes treated with accelerated CXL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4fa284e2b881ce1fcd597398e8b24fc5 https://doi.org/10.2147/opth.s232118 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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