Some Hypothalamic Hamartomas Contain Transforming Growth Factorα , a Puberty-Inducing Growth Factor, But Not Luteinizing Hormone-Releasing Hormone Neurons1
| Autor: | J. H. Piatt, M. S. Schwartz, Anda Cornea, Maria E. Costa, Sergio R. Ojeda, K. H. P. Bentele, Ying Jun Ma, J. W. Witkin, P. Carmel, Heike Jung, M. Westphal |
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| Rok vydání: | 1999 |
| Předmět: |
endocrine system
medicine.medical_specialty TGF alpha Endocrinology Diabetes and Metabolism Growth factor medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Biology medicine.disease Biochemistry Hypothalamic disease Endocrinology nervous system Hypothalamus Internal medicine medicine Precocious puberty Receptor Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 84:4695-4701 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.84.12.6185 |
| Popis: | Activation of LH-releasing hormone (LHRH) secretion, essential for the initiation of puberty, is brought about by the interaction of neurotransmitters and astroglia-derived substances. One of these substances, transforming growth factor alpha (TGFalpha), has been implicated as a facilitatory component of the glia-to-neuron signaling process controlling the onset of female puberty in rodents and nonhuman primates. Hypothalamic hamartomas (HH) are tumors frequently associated with precocious puberty in humans. The detection of LHRH-containing neurons in some hamartomas has led to the concept that hamartomas advance puberty because they contain an ectopic LHRH pulse generator. Examination of two HH associated with female sexual precocity revealed that neither tumor had LHRH neurons, but both contained astroglial cells expressing TGFalpha and its receptor. Thus, some HH may induce precocious puberty, not by secreting LHRH, but via the production of trophic factors--such as TGFalpha--able to activate the normal LHRH neuronal network in the patient's hypothalamus. |
| Databáze: | OpenAIRE |
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