The Different Effect of Sucrose on Transcriptomic Profile in Adipose and Muscle Tissues in Model of Metabolic Syndrome and Insulin Resistance
| Autor: | Ondrej Seda, Martina Hüttl, Irena Markova, Hana Malinska, Ludmila Kazdova |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Sucrose Endocrinology Diabetes and Metabolism Adipose tissue Context (language use) Biology medicine.disease Transcriptome chemistry.chemical_compound Insulin resistance Endocrinology chemistry Internal medicine Lipogenesis Internal Medicine medicine Metabolic syndrome Beta oxidation |
| Zdroj: | Diabetes. 67 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | The development and progression of insulin resistance is driven by genetic and enviromental factors and their interactions. Sucrose belongs to nutrition factors with lipogenic impact, induces de novo lipogenesis, reduces fatty acid oxidation and can deteriorate insulin sensitivity. The aim of study was to investigate transcriptome profile in adipose and muscle tissues under standard or high sucrose diet (HSD) (70 kcal% as sucrose) in two strains of rats - Wistar and a strain of hereditary hypertriglyceridemic rats (HHTg) as a polygenic model of metabolic syndrome and insulin resistance. The transcriptome analysis was evaluated in the context of development and progression of insulin resistance. HSD feeding in 2 weeks increased epididymal adipose tissue (EAT) weight in both strains (P diet In conclusion, HSD feeding impaired insulin sensitivity in both rat strains. Transcriptomic alterations in adipose tissue precede muscle changes caused by HSD and show distinct patterns in genetically susceptible HHTg model of metabolic syndrome. Disclosure M. Hüttl: None. I. Marková: None. H. Malinska: None. L. Kazdova: None. O. Seda: None. |
| Databáze: | OpenAIRE |
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