VITAMIN A POISONING
| Autor: | Donald Gribetz, Samuel H. Silverman, Albert E. Sobel |
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| Rok vydání: | 1951 |
| Předmět: | |
| Zdroj: | Pediatrics. 7:372-385 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.7.3.372 |
| Popis: | Two cases of hypervitaminosis A have been presented together with a review of experimental and clinical literature. The first case presented the highest reported fasting plasma vitamin A level, the increase being chiefly due to a high vitamin A alcohol fraction. This elevated level of alcoholic vitamin A probably denotes large stores of vitamin A in the liver and data have been given to show that it is a better index of hypervitaminosis A than is the total vitamin A level. In addition, evidence has been presented that the toxic factor in hypervitaminosis A is the permanent elevated plasma vitamin A level. The similarity between the experimental studies in animals and the observations in the authors' first case has been shown. The important points necessary for making a diagnosis of hypervitaminosis A have been discussed and several similar conditions have been differentiated. It cannot be emphasized too strongly that excess vitamin intake may be as dangerous as a deficient intake. |
| Databáze: | OpenAIRE |
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