Prospective evaluation of the impact of covert hepatic encephalopathy on quality of life and sleep in cirrhotic patients
| Autor: | Tim Zimmermann, Yvonne Huber, J. S. Baron, MA Wörns, Michael Nagel, Gerrit Toenges, Jens U. Marquardt, M Nguyen-Tat, Martin F. Sprinzl, Christian Labenz, Peter R. Galle, Jörn M. Schattenberg |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis Hepatology Psychometrics business.industry Gastroenterology Chronic liver disease medicine.disease humanities Pittsburgh Sleep Quality Index 03 medical and health sciences 0302 clinical medicine Quality of life 030220 oncology & carcinogenesis Internal medicine Medicine 030211 gastroenterology & hepatology Pharmacology (medical) business Prospective cohort study Hepatic encephalopathy Cohort study |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 48:313-321 |
| ISSN: | 0269-2813 |
| Popis: | BACKGROUND Minimal hepatic encephalopathy (HE) and HE grade 1 (HE1) according to the West Haven criteria have recently been grouped as one entity named-covert HE- (CHE). Data regarding the impact of CHE on health-related quality of life (HRQoL) and sleep quality are controversial. AIM First, to determine whether CHE affects HRQoL and sleep quality of cirrhotic patients and second, whether minimal HE (MHE) and HE1 affect HRQoL and sleep quality to a comparable extent. METHODS A total of 145 consecutive cirrhotic patients were enrolled. HE1 was diagnosed clinically according to the West Haven criteria. Critical flicker frequency and the Psychometric Hepatic Encephalopathy Score were used to detect MHE. Chronic Liver Disease Questionnaire (CLDQ) was used to assess HRQoL and Pittsburgh Sleep Quality Index (PSQI) was applied to assess sleep quality. RESULTS Covert HE was detected in 59 (40.7%) patients (MHE: n = 40; HE1: n = 19). Multivariate analysis identified CHE (P |
| Databáze: | OpenAIRE |
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