| Popis: |
Cryptotanshinone, tanshinone I, and tanshinone IIA were analyzed by High-performance liquid chromatography /electrospray ionization-mass spectrometry. MSn spectra were obtained and optimized by energy collision induced dissociation (CID) from [M+H]+ ions, the effect of collision energy on production of fragmental ions were studied and optimal signals were achieved. With the collision energy of 35%, tanshinones have optimal signals of fragmental ions and maximal amounts of product fragment ions respectively. The fragmentation pathways for the compounds were studied, and this information would be helpful for the quantitative and pharmacokinetic analysis of tanshinones. |
