Novel amino acid-based polymers for pharmaceutical applications
| Autor: | Miklós Zrínyi, Árpád Némethy, Béla Noszál, Viktoria Torma, Zoltán Szakács, Tamás Gyenes |
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| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Condensation polymer Polymers and Plastics Chemistry General Chemistry Condensed Matter Physics Photo-reactive amino acid analog Amino acid Hydrolysis chemistry.chemical_compound Deprotonation Succinimide Aspartic acid Materials Chemistry Side chain Organic chemistry |
| Zdroj: | Polymer Bulletin. 59:311-318 |
| ISSN: | 1436-2449 0170-0839 |
| Popis: | Entirely amino acid-based polymers were prepared by side-chain attachment to polysuccinimide derived from the thermal polycondensation of aspartic acid. Following deprotonation of various amino acid ester hydrochlorides by a secondary amine, the restored primary amino groups initiated the ring-opening of succinimide to form amide bonds. 1H and 13C NMR measurements revealed that the mole fraction of the introduced amino acid side chains could be controlled by the reaction time, while no hydrolysis of methyl ester groups was observed. The synthesized polymers contain exclusively amino acids, which makes them promising candidates as base materials of controlled drug delivery systems. |
| Databáze: | OpenAIRE |
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