ChemInform Abstract: Synthesis and Structure-Activity Relationships of Potent 1-(2-Substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine Dipeptidyl Peptidase IV Inhibitors

Autor:	Akira Hiratate, Yuji Takaoka, Hidetaka Saito, Koji Yamamoto, Masato Takahashi, Masako Saito-Hori, Eiji Munetomo, Hiroshi Fukushima, Kiyokazu Kitano
Rok vydání:	2009
Předmět:	Glucose lowering chemistry.chemical_compound Chemistry In vivo General Medicine Pharmacology Dipeptidyl peptidase Pyrrolidine Dipeptidyl-Peptidase IV Inhibitors
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200903194
Popis:	Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for use in the treatment of type 2 diabetes because they prevent the degradation of glucagon-like peptide-1 (GLP-1) and extend its duration of action. We previously reported that 2-cyano-4-fluoropyrrolidines act as potent DPP-IV inhibitors and have been modifying the 1-position of pyrrolidine to obtain more useful inhibitors. An L-tert-butylglycine derivative was found to be a stable and potent DPP-IV inhibitor that exhibits a glucose lowering effect in vivo. Here, we report the synthesis of and biological data on the aforementioned derivatives.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4f810c958e9575a34e8e4068e27ac6f2 https://doi.org/10.1002/chin.200903194 Zobrazit plný text záznamu Plný text