Hepatitis B in hemodialysis patients: Significance of HBeAg
| Autor: | George L. Le Bouvier, Denis J. Miller, John M. Dwyer, Gerald Klatskin, Alan Williams, James Grant |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
HBsAg Immune status Hepatology business.industry viruses medicine.medical_treatment Gastroenterology virus diseases Poor responsiveness Hepatitis B medicine.disease Virology digestive system diseases Peripheral blood HBeAg Internal medicine medicine Hemodialysis business Normal range |
| Zdroj: | Gastroenterology. 74:1208-1213 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/0016-5085(78)90694-7 |
| Popis: | Twenty-four HBsAg-positive (HBsAg + ) hemodialysis patients were prospectively studied to assess (1) the prognostic value of HBeAg and its HBe 1 Ag and HBe 2 Ag components and (2) whether a difference in cellular immune status between HBeAg + and HBeAg-negative (HBeAg − ) patients could be defined. Sixteen patients were HBeAg + and 8 were HBeAg − initially. After a mean follow-up period of 23.7 months, it was concluded that the initial presence of HBeAg correlated with the persistence of HBsAg because 15 of the 16 HBeAg + patients were still HBsAg + at death or last follow-up, whereas 7 of the 8 HBeAg − patients had become HBsAg − at a mean period of 3.8 months. HBe 1 Ag was consistently present in 15 of the 16 patients when HBeAg was detectable, whereas HBe 2 Ag fluctuated widely in individual patients over time. No difference in cellular immune status between HBeAg + and HBeAg − patients could be defined; although both HBeAg + and HBeAg − patients had a similar decrease in peripheral blood T cells and poor responsiveness to purified HBsAg, both groups of patients had stimulation indices to nonspecific mitogens within the normal range. |
| Databáze: | OpenAIRE |
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